胰腺癌手術前接受化療放療可延長生存期
來自專欄基於基因組學診斷的癌症靶向治療5 人贊了文章
2018年的美國臨床癌症學協會ASCO年會報告了一個胰腺癌3期臨床試驗PREOPANC-1的結果,研究焦點是可以手術的胰腺癌患者是應該馬上手術好,還是先接受短時間的放療和吉西他濱化療再做手術比較好。官網鏈接如下,醫生可以直接閱讀原文:
2018 ASCO: PREOPANC-1 Trial Compares Preoperative Chemoradiotherapy vs Immediate Surgery for Pancreatic CancerKey Findings
The median overall survival was 17.1 months with preoperative chemoradiotherapy compared to 13.7 months (P = .74) with immediate surgery. The time until pancreatic cancer recurrence was longer with preoperative therapy (9.9 vs 7.9 months, P = .023). The chance of surviving longer than 2 years was also higher with preoperative treatment than with immediate surgery (42% vs 30%). Among patients in whom the tumor was surgically removed successfully, the difference in median survival was even greater: 42.1 months with preoperative treatment vs 16.8 months with immediate surgery.
重要發現:
- 手術前放化療的患者總體中位生存期是17.1個月, 直接手術的患者總體中位生存期是13.7個月。
2. 2年生存期手術前放化療的病人是42%, 直接手術的是30%。
3. 腫瘤成功切除的胰腺癌病人裡面,手術前放化療的病人中位生存期是42.1個月, 直接手術的病人是16.8個月。
從ASCO年會的報告到文章的發表至少會有半年的延後時間,從文章的發表到國內的醫生閱讀後做出臨床治療方案調整估計又有半年時間,加起來就有1年了。 而胰腺癌非常兇險,很多病人拖不起這個時間,所以我才寫成文章發布在知乎上, 希望可以引起病人家屬和臨床醫生的注意。
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