胃食管返流癥狀與慢性阻塞性肺病加重有關

06-19

【科普】胃食管返流癥狀與慢性阻塞性肺病加重有關

cxw129

56積分

0得票

2粉絲

加關注

2008-12-07 17:17 消息引用收藏分享

分享到哪裡？

複製網址

新浪微博

豆瓣社區

騰訊微博

開心網

人人網

只看樓主

Symptoms of GERD Linked to COPD ExacerbationNEW YORK (Reuters Health) Nov 26 - Results of a study published in the November issue of Thorax suggest that symptoms of gastroesophageal reflux disease (GERD) are an important factor associated with exacerbations in chronic obstructive pulmonary disease (COPD).Dr. S. Muro of Kyoto University, Japan, and colleagues prospectively examined the association between GERD symptoms and COPD exacerbations in 82 patients with COPD and 40 age-matched controls over a 6-month period.Overall, 22 COPD patients (26.8%) and five controls (12.5%) reported positive GERD symptoms. The incidence of COPD exacerbation was significantly higher in patients with GERD symptoms than in those without symptoms (relative risk 1.93; p < 0.01).Results of multiple regression analysis revealed a significant association between GERD symptoms and the occurrence of exacerbations (RR 6.55; p < 0.01).The authors report that the exhaled breath condensate (EBC) pH was inversely associated with the GERD symptom score in patients with COPD and in controls. However, EBC pH was not significantly correlated with COPD exacerbation frequency."It is difficult to determine whether (GERD) itself directly affects exacerbation or merely coexists in patients who experience frequent exacerbations," Dr. Muro"s team comments. "Further examinations are needed to clarify whether treatment for (GERD) symptoms ameliorates COPD exacerbations."Thorax 2008;63:951-955.胃食管返流癥狀與慢性阻塞性肺病加重有關（紐約路透電）11月26日-刊登在Thorax 11期的一份研究結果表明，胃食管返流（G ERD）癥狀是與慢性阻塞性肺疾病（COPD）加重有關的一個重要因素日本京都大學S. Muro博士和同事們進行了一項為期6個月的前瞻性研究，觀察82例慢性阻塞性肺病和40名年齡匹配的對照人群胃食管反流病癥狀和慢性阻塞性肺疾病加重之間的聯繫。總的來說，22例COPD病人(26.8%)和5個對照組(12.5%)報告GERD癥狀陽性，有GERD癥狀患者的COPD加重發生率明顯高於無GERD癥狀的患者（相對危險度1.93; p < 0.01）多元回歸分析結果顯示胃食管反流病癥狀和加重發生率存在顯著相關性(RR 6.55; p < 0.01).報告指出，呼出氣冷凝液(EBC) pH值與COPD患者和對照人群胃食管反流病癥狀評分負相關。然而， EBC pH值與COPD發作頻率無顯著相關性。Muro博士的研究團隊評論道「尚難以確定那些頻繁發作的患者，GERD本身直接影響發作頻率抑或僅僅是合併症，進一步搞清治療GERD是否減少COPD加重是必要的。」

0票

票數