Jxb∣擬南芥中衰老相關轉錄因子的遺傳冗餘

02-03

2017年12月22日，該文章在線發表於Jxb。本文為一篇綜述文章，第一作者為李中海，通訊作者為韓國的Hye Ryun Woo和南方科技大學的郭紅衛。文章講述了衰老相關基因（SAGs）在調控葉片衰老過程的冗餘功能。

原題目為：

Genetic redundancy of senescence-associated transcription factors in Arabidopsis

摘要：

葉片衰老是構成葉片發育最後階段的遺傳程序化過程，涉及到基因表達的巨大變化。作為闡明葉片衰老過程中分子遺傳機制的努力的結果，在過去二十年中，已經在擬南芥中鑒定了184個基因，它們在突變或過表達時會改變葉片衰老表型。同時，衰老相關基因（SAGs）中功能冗餘的實驗證據也有所增加。本文綜述了擬南芥葉片衰老過程中轉錄因子發揮調控的作用，闡述了基因複製，基因表達水平和衰老表型之間的關係。以前的發現和我們的重新分析表明，重複SAGs對的普遍存在，重複基因的基因表達水平之間的相關性，以及相應的突變體與衰老相關表型的嚴重性。我們還強調了可用於冗餘SAG功能分析的有效和強大的工具。對重複SAGs對的研究提供了一個獨特的機會來了解葉片衰老的調控，並可以通過反向遺傳方法指導冗餘SAGs功能的研究。

Abstract：

Leaf senescence is a genetically programmed process that constitutes the last stage of leaf development, and involves massive changes in gene expression. As a result of the intensive efforts that have been made to elucidate the molecular genetic mechanisms underlying leaf senescence, 184 genes that alter leaf senescence phenotypes when mutated or overexpressed have been identified in Arabidopsis thaliana over the past two decades. Concurrently, experimental evidence on functional redundancy within senescence-associated genes (SAGs) has increased. In this review, we focus on transcription factors that play regulatory roles in Arabidopsis leaf senescence, and describe the relationships among gene duplication, gene expression level, and senescence phenotypes. Previous findings and our re-analysis demonstrate the widespread existence of duplicate SAG pairs and a correlation between gene expression levels in duplicate genes and senescence-related phenotypic severity of the corresponding mutants. We also highlight effective and powerful tools that are available for functional analyses of redundant SAGs. We propose that the study of duplicate SAG pairs offers a unique opportunity to understand the regulation of leaf senescence and can guide the investigation of the functions of redundant SAGs via reverse genetic approaches.

每日一詞
concurrently
英[k?nk?r?ntl?]
美[k?nk?:?ntl?]

adv. 同時地;