Nature Plants∣長壽橡樹中固定體細胞的突變數量較少

本論文於2017年12月4日發表於Nature Plants，原文題目如下：

Low number of fixed somatic mutations in a long-lived oak tree

摘要：

由於植物不具有確定的種系，有害的體細胞突變可以傳遞給配子，將合子與配子形成分開的大量的細胞分裂可能導致長壽植物的許多突變。我們對234歲橡樹的兩個末端分支進行了基因組測序，發現了幾個固定的體細胞單核苷酸變異體，並且可以沿著更年輕分支的嵌套部分追蹤它們在樹上的順序。 我們的數據表明，樹上頂端分生組織幹細胞被強烈的保護著，從而免於突變的積累。

Abstract：

Because plants do not possess a defined germline, deleterious somatic mutations can be passed to gametes, and a large number of cell divisions separating zygote from gamete formation may lead to many mutations in long-lived plants. We sequenced the genome of two terminal branches of a 234-year-old oak tree and found several fixed somatic singlenucleotide variants whose sequential appearance in the tree could be traced along nested sectors of younger branches. Our data suggest that stem cells of shoot meristems in trees are robustly protected from the accumulation of mutations.

每日一詞

deleterious

英[?del??t??ri?s]

美[?del??t?ri?s]

adj. 有害的; 有毒;

[例句]Petty crime is having a deleterious effect on community life.

輕微罪行正對社區生活產生有害影響。

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