吡啶是怎麼傷害人的身體的？

01-05

Pyridine is harmful if inhaled, swallowed or absorbed through the skin.[117] Effects of acute pyridine intoxication include dizziness, headache,lack of coordination, nausea, salivation, and loss of appetite. They may progress into abdominal pain, pulmonary congestion and unconsciousness.[118] One person died after accidental ingestion of half a cup of pyridine.[25] The lowest known lethal dose (LDLo) for the ingestion of pyridine in humans is 500 mg·kg?1. In high doses, pyridine has a narcotic effect and its vapor concentrations of above 3600 ppmpose a health risk.[48] The oral LD50 in rats is 891 mg·kg?1. Pyridine is flammable.
Evaluations as a possible carcinogenic agent showed that there is inadequate evidence in humans for the carcinogenicity of pyridine, although there is limited evidence of carcinogenic effects on animals.[118] Available data indicate that "exposure to pyridine in drinking-water led to reduction of sperm motility at all dose levels in mice and increased estrous cycle length at the highest dose level in rats".[118]

Pyridine might also have minor neurotoxic, genotoxic, and clastogenic effects.[17][25][119] Exposure to pyridine would normally lead to its inhalation and absorption in the lungs and gastrointestinal tract, where it either remains unchanged or ismetabolized. The major products of pyridine metabolism are N-methylpyridiniumhydroxide, which are formed by N-methyltransferases (e.g., pyridine N-methyltransferase), as well as pyridine N-oxide, and 2-, 3-, and 4-hydroxypyridine, which are generated by the action of monooxygenase. In humans, pyridine is metabolized only into N-methylpyridiniumhydroxide.[17][119] Pyridine is readily degraded by bacteria to ammonia and carbon dioxide.[120] The unsubstituted pyridine ring degrades more rapidly than picoline, lutidine, chloropyridine, or aminopyridines,[121] and a number of pyridine degraders have been shown to overproduce riboflavin in the presence of pyridine.[122] Ionizable N-heterocyclic compounds, including pyridine, interact with environmental surfaces (such as soils and sediments) via multiple pH-dependent mechanisms, including partitioning to soil organic matter, cation exchange, and surface complexation.[123]Such adsorption to surfaces reduces bioavailability of pyridines for microbial degraders and other organisms, thus slowing degradation rates and reducing ecotoxicity.[124]
Minor amounts of pyridine are released into environment from some industrial processes such as steel manufacture,[125]processing of oil shale, coal gasification, coking plants and incinerators.[25] The atmosphere at oil shale processing plants can contain pyridine concentrations of up to 13 μg·m?3,[126] and 53 μg·m?3 levels were measured in the groundwater in the vicinity of a coal gasification plant.[127] According to a study by the US National Institute for Occupational Safety and Health, about 43,000 Americans work in contact with pyridine.[128]

Pyridine Wikipedia

苦，真tm苦，帶幾層口罩都不頂用。沾到皮膚上火辣辣的疼，跟DCM有的一拼。具體傷害不清楚，不過吡啶作為弱鹼性試劑，經常在需要弱鹼環境的反應中用到，毒性應該不大的，估計還沒有丙酮大。

男不用呋喃，女不用吡啶、這種說法不知道從哪裡出來的，但是感覺這兩種芳香雜環相對比較穩定，另外既然分了性別，肯定是與生殖系統相關。但是參考雌激素、雄激素的結構也沒看出太多的相關性。個人認為與芳香環可以與DNA發生嵌入效應而影響複製和表達相關。總之是少接觸好，實在避免不了，多運動，多喝水，早換工作！

抖個機靈

pyridine交易當然傷害人體啦

怎樣傷害的重要嗎？少用就是了